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Banner — University Medical Center Phoenix  
Faculty
 

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Steve Curry, MD, FACMT, FAACT
Director
Department of Medical Toxicology, Banner — University Medical Center Phoenix
Professor of Medicine, University of Arizona College of Medicine - Phoenix
Undergraduate: Bradley University
Medical School: Southern Illinois University School of Medicine
Residency Emergency Medicine: Methodist Hospital, Indianapolis
Fellowship: Medical Toxicology St. Luke's Hospital Phoenix, AZ
Board Certification: Medical Toxicology Emergency Medicine
Areas of Interest: neurotoxicology, mitochondrial dysfunction, critical care medicine, cyanide, salicylate, methemoglobinemia, nitroprusside cyanogenesis, Crotalinae envenomation, rhabdomyolysis, sodium channel blockade, occupational and environmental toxicology, medical effects of hazardous materials, cardiovascular drugs and toxins

Dr. Curry's Publications

Abbreviated lists of publications:
Journals:
 

"Methemoglobinemia;" Annals of Emergency Medicine. 1982; 11:214.

"Envenomation by the scorpion Centruroides sculpturatus;" Journal of Toxicology-Clinical Toxicology. 1984; 21:417.

"Reptile envenomations;" Journal of Toxicology-Clinical Toxicology. 1984; 21:503.

"Death from a rattlesnake bite;" American Journal of Emergency Medicine. 1985; 3:227.
 
"Cardiovascular effects of toxic concentrations of theophylline in the dog;" Annals of Emergency Medicine. 1985; 14:547.

"The effects of toxic concentrations of theophylline on oxygen consumption, ventricular work, acid/base balance, and plasma catecholamine levels in the dog;" Annals of Emergency Medicine. 1985; 14:554.

"Intravenous mushroom poisoning;" Annals of Emergency Medicine. 1985; 14:900.

Value of non-invasive vascular studies in management of rattlesnake envenomations to extremities. Annals of Emergency Medicine 1985; 14:1081.
 
Veterinary euthanasia drugs as suicide agents. Annals of Emergency Medicine 1986; 15:939.

First-order elimination kinetics following baclofen overdose. Annals of Emergency Medicine 1986; 15:843.

Treatment of digital hydrofluoric acid burns with intraarterial calcium salt infusions. Annals of Emergency Medicine 1986; 15:890.

Life-threatening anaphylaxis following Gila monster bite. Annals of Emergency Medicine 1986; 15:959.

Prolonged succinylcholine-induced paralysis in organophosphate insecticide poisoning. Annals of Emergency Medicine 1987; 16:215.

Life-threatening airway obstruction from rattlesnake bite to the tongue. Annals of Emergency Medicine 1987; 16:813.

Lack of correlation between plasma 4-hydroxyglutethimide and severity of coma in acute glutethimide poisoning. A case report and brief review of the literature on 4-hydroxyglutethimide. Medical Toxicology 1987; 2:309. 
 
Successful treatment with antivenin of marked thrombocytopenia without significant coagulopathy following rattlesnake bite. Annals of Emergency Medicine 1987; 16:1297.
 
Pemoline-induced choreoathetosis and rhabdomyolysis. Medical Toxicology 1988; 3:72.

Serial serum drug concentrations and prolonged anticholinergic toxicity after benztropine (Cogentin) overdose. American Journal of Emergency Medicine 1989; 7:199.

The legitimacy of rattlesnake bites in central Arizona. Annals of Emergency Medicine 1989, 18:658.

 Phenytoin absorption in volunteers receiving selected enteral feedings.  Western Journal of Medicine 1989; 150:659.

A rattlesnake bite to the tongue. Annals of Emergency Medicine 1988; 17:54 (letter).

Drug and toxin-induced rhabdomyolysis. Annals of Emergency Medicine 1989;10:1068.
 
An ovine model of maternal iron poisoning in pregnancy.  Maternal and fetal serum iron concentrations with and without maternal deferoxamine therapy.  Annals of Emergency Medicine 1990;19:632.

Dimethylsulphoxide-induced encephalopathy.  Lancet 1989; 1:1134.

Acute lead poisoning in nursing home and psychiatric patients from the ingestion of lead-based ceramic glazes.  Archives of Internal Medicine 1990;150:2085.

Refractory hypoglycemia secondary to topical salicylate intoxication.  Archives of Internal Medicine 1991;151:591.
 
Marijuana.  Emergency Medicine Clinics of North America 1990;8:527.

Lovastatin use and muscle damage in healthy volunteers undergoing eccentric muscle exercise.  Western Journal of Medicine 1991;154:198.
 
Lack of evidence of a percent saturation gap in cyanide poisoning.  Annals of Emergency Medicine 1991;20:523.
 
Digoxin-specific Fab fragments in the treatment of oleander toxicity in a canine model.  Annals of Emergency Medicine 1991;20:1073.

Transplacental transport of N-acetylcysteine in an ovine model.  Annals of Emergency Medicine 1991;20:1069.

The influence of glycol ethers on plasma osmolality.  Human and Experimental Toxicology 1992;11:488.

Clinical toxicology of ethylene glycol monoalkyl ethers. Human and Experimental Toxicology 1993;13:325.

The effect of the cyanide antidote hydroxocobalamin on commonly ordered serum chemistry studies.  Annals of Emergency Medicine 1994;24:65.

Acute iron poisoning.  Emergency Medicine Clinics of North America 1994;12:397.

Time until emesis on the efficacy of decontamination using acetaminophen as a marker in a pediatric population.  Ann Emerg Med 1993;22:1403.

Organophosphate-associated "intermediate syndrome": for real?  AACT Clinical Toxicology Update 1994;7:1 (commentary).
 
The effect of hypertonic sodium bicarbonate on QRS duration and blood pressure in rats poisoned with chloroquine.  Clin Toxicol 1996;34:73.
 
Anticonvulsant hypersensitivity syndrome.  Emergency Medicine (Australia) 1995;7:170.

Pool cue chalk as a course of environmental lead.  Pediatrics 1995;97:916.

Prevention of fetal and maternal cyanide toxicity from nitroprusside with co-infusion of sodium thiosulfate in gravid ewes.  Anesthesia & Analgesia 1997;84:1121.

Poisoning by sodium channel blocking agents.  Critical Care Clinics 1997;13:829.

Crotalid snake envenomation.  Critical Care Clinics 1997;13:889.

Affinity-purified, mixed monospecific crotalid antivenom ovine Fab for the treatment of Crotalid venom poisoning.  Ann Emerg Med 1997;30:33.
 
Effect of magnesium hydroxide on iron absorption following simulated mild iron overdose in human subjects.  Academic Emergency Medicine 1998;5:961-965.

Butyrolactone-induced CNS depression after ingestion of RenewTrient, a "Dietary Supplement".  New England Journal of Medicine 1998;339:847 (letter).

Renal failure and corrosive airway and gastrointestinal injury following ingestion of dilute diquat solution.  Annals of Emergency Medicine 1999;34:542-545.

Lack of transplacental movement of the cyanide antidote, thiosulfate, in gravid ewes.  Anaesthesia & Analgesia, 2000;89:1448-1452.
 
 Failure of intravenous N-acetylcysteine to enhance reduction of methemoglobin produced by sodium nitrite in human volunteers.  Annals of Emergency Medicine 2000;35:369-73

Methamphetamine toxicity.  Pediatric Emergency Care 1999;15:306 (letter).

Crack cocaine ingestion with prolonged toxicity requiring electrical pacing.  J Toxicol Clin Toxicol 2000;38:653-657.

Incidence of immediate and delayed hypersensitivity to Centruroides antivenom.  Annals of Emergency Medicine 1999;34:615-619.

Hypertonic sodium bicarbonate is effective in the acute management of verapamil toxicity in a swine model.  Annals of  Emergency Medicine  2000;36:547-553.

Rattlesnake Envenomation: Unusual Case Presentations.  Archives of Internal Medicine 2001;161:474-479.

Epidemiology and hospital course of rattlesnake envenomations cared for at a tertiary referral center in Central Arizona.  Academic Emergency Medicine 2001;8:177-182.

Combined ingestion and subcutaneous injection of elemental mercury.  Journal of Emergency Medicine 2001;20:39-42.

Hemolytic anemia after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency.  American Journal of Medicine 2001;110:240-241 (letter).

Intravenous pyridoxine-induced metabolic acidosis.  Annals of Emergency Medicine 2001;38:62-64.

Diagnostic use of physicians' detection of urine fluorescence in a simulated ingestion of sodium fluorescein-containing antifreeze.  Annals of Emergency Medicine 2001;38:49-54.

A randomized multicenter trial of Crotalinae polyvalent immune Fab (ovine) antivenom for the treatment for crotaline snakebite in the United States.  Archives of Internal Medicine 2001;161:2030-2036.

Hypertonic sodium bicarbonate for Taxus media-induced cardiac toxicity in swine.  Academic Emergency Medicine 2002;9:179-185.

Initial postmarketing experience with CroFab for treatment of rattlesnake envenomation.  Annals of Emergency Medicine 2002; 39:609-615.

Postcollection rise in methemoglobin level in frozen blood specimens.  J Toxicol Clin Toxicol  2002:40(1):91-94.
 
The effect of cyclosporine A on survival time in salicylate-poisoned rats.  J Emerg Med 2004; 26:151-155.

Aniline and methanol toxicity after shoe dye ingestion.  J Emerg Med 2004;27:367-369.
 
False positive acetaminophen levels associated with hyperbilirubinemia.  J Toxicol Clin Toxicol.  2005,43:167-170.

Acute tellurium toxicity from ingestion of metal oxidizing solutions. Pediatrics. 2005 Aug;116(2):e319-21. Epub 2005 Jul 1.

Intraventricular conduction delay after bupropion overdose. Journal of Emergency Medicine 2005;29:299-305.

The effect of single-dose tramadol on oxycodone clearance. Journal of Emergency Medicine 2007;33:407-411.

Effect of intravenous albumin infusion on brain salicylate concentration. Academic Emergency Medicine 2007;14:508-514.

Results of a protocol for the management of patients with fulminant liver failure. Critical Care Medicine 2008;36:2244-2248.

Poison Control Centers Decrease Emergency Healthcare Utilization Costs. Journal of Medical Toxicology 2008;4:221-224.

Urine mercury excretion following DMSA in fish eaters. Archives of Pathology and Laboratory Medicine 2009;133:87-92.

Recombinant Factor VIIa for Treatment of gastrointestinal hemorrhage following rattlesnake envenomation. Wilderness and Environmental Medicine 2009;20:156-160.

Late hematologic toxicity following treatment of rattlesnake envenomation with Crotalidae polyvalent immune Fab antivenom. Toxicon 2011 57;53-59.

Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop. BMC Emergency Medicine 2011;11:2 (3 Feb 22011).

Prolonged toxicity after amitriptyline overdose in a patient deficient in CYP2D6 activity. Journal of Medical Toxicology 2011;7:220-223.

Ethylene glycol elimination kinetics and outcomes in patients managed without hemodialysis. Annals of Emergency Medicine 2012 [Epub ahead of print].

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. Journal of Clinical Investiation 2012;122:1574-1583.

Plasma and urine dimercaptopropanesulfonate concentrations after dermal application of transdermal DMPS (TD-DMPS). Journal of Medical Toxicology 2013;9:9-15.

Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25 year experience at a single center. Annals of Emergency Medicine 2013, May 1 (Epub ahead of print).

Improving clinical interpretation of the anti-platelet factor 4/heparin ELISA for the diagnosis of heparin-induced thrombocytopenia through the use of receiver operating characteristic analysis, stratum specific likelihood ratios and Bayes theorem. Chest 2013, May 23 (Epub ahead of print)

Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. Archives of Toxicology 2014;88:391-401.

Effect of a medical toxicology admitting service on length of stay, cost and mortality among inpatients discharged with poisoning-related diagnoses. Journal of Medical Toxicology, in press, July 2014

Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis. PNAS doi:10:1073/pnas. 1412608111, ahead of print August 4, 2014

Prolonged acetaminophen-protein adduct elimination during renal failure, lack of adduct removal by hemodiafiltration, and urinary adduct concentrations after acetaminophen overdose. Journal of Medical Toxicology 2014 Oct 7 [Epub ahead of print].

Glycodeoxycholic acid levels as prognostic biomarkers in acetaminophen-induced acute liver failure patients. Toxicological Sciences 2014;142:436-444.

Quantification of a biomarker of acetaminophen protein adducts in human serum by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: clinical and animal model applications. J Chromatogr B Analyt Technol Biomed Life Sci 2015; Jan 24; Epub ahead of print.

Book Chapters (Abreviated list):

Heavy Metals, in Aghababian R, Allison EJ, Braen GR, Fleisher J, et al. (eds):  Emergency Medicine.  Lippincott, Philadelphia, 1998:1113.
 
 Methemoglobinemia, in Harwood-Nuss AL, Linden CH, Sternbach G, Wolfson AB (eds), 3rd ed: The Clinical Practice of Emergency Medicine. Lippincott-Raven, Philadelphia, 2000:1544.
 
 Black Widow Spider Envenomations, in Harwood-Nuss AL, Linden CH, Sternbach G, Wolfson AB (eds), 3rd  ed: The Clinical Practice of Emergency Medicine. Lippincott-Raven, Philadelphia, 2000:1636.
 
Neurotransmitters, Chapter 10, in Goldfrank LR, Flomenbaum NE, Lewin NA, Howland MA, et al, eds:  Goldfrank's Toxicologic Emergencies.  McGraw-Hill, New York, 7th edition, 2002:133-165.

Poisoning in pregnancy, in Foley MR, Strong TH, Garite TJ (eds), 2nd ed.:  Obstetric Intensive Care Manual.  McGraw-Hill, New York, 2004:298-315.

Hematologic syndromes:  hemolysis, methemoglobinemia, and sulfhemoglobinemia, in Brent J, et al, eds:  Critical Care Toxicology:  Diagnosis and Management of the critically Poisoned Patient.  Elsevier Mosby, Philadelphia, 2005:335-344.

Sodium nitroprusside, in Brent J, et al, eds:  Critical Care Toxicology:  Diagnosis and Management of the critically Poisoned Patient.  Elsevier Mosby, Philadelphia, 2005:435-440.

Salicylates, in Brent J, et al, eds:  Critical Care Toxicology:  Diagnosis and Management of the critically Poisoned Patient.  Elsevier Mosby, Philadelphia, 2005:621-630.

Thrombolytics, heparin and derivatives, and antiplatelet agents, in Brent J, et al, eds:  Critical Care Toxicology:  Diagnosis and Management of the critically Poisoned Patient.  Elsevier Mosby, Philadelphia, 2005:701-710.

Oral Anticoagulants, in Brent J, et al, eds:  Critical Care Toxicology:  Diagnosis and Management of the critically Poisoned Patient.  Elsevier Mosby, Philadelphia, 2005:695-700.

Cyanide:  hydrogen cyanide, inorganic cyanide salts, and nitriles, in Brent J, et al, eds:  Critical Care Toxicology:  Diagnosis and Management of the critically Poisoned Patient.  Elsevier Mosby, Philadelphia, 2005:987-998.

Scorpion envenomation, in Wolfson AB, et al, eds: The Clinical Practice of Emergency Medicine. Lippincott Williams & Wilkins, Philadelphia, 2005, 1731-1734.

Iron, in Wolfson AB, et al, eds: The Clinical Practice of Emergency Medicine. Lippincott Williams & Wilkins, Philadelphia, 2005, 1596-1599.

Neurotransmitters and neuromodulators. In Goldfrank's Toxicologic Emergencies, 8th ed, McGraw-Hill, New York 2006

Hematologic consequences of Poisoning. Chapter 14. In, Shannon MW, Borron SW, Burns MJ, eds: Clinical Management of Poisoning and Drug Overdose, 4th Edition, Saunders Elsevier, Philadelphia, 2007, pp 289-300.

Neurotransmitters and Neuromodulators, Chapter 13, in Nelson LS, Lewin NA, Howland MA, Hoffman RS, Goldfrank LR, Flomenbaum NE, eds: Goldfrank's Toxicologic Emergencies. McGraw Hill, New York, 9th edition, 2010, pp 189-220.

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